Nanolive

𝗤𝘂𝗮𝗻𝘁𝗶𝗳𝘆 𝗶𝗺𝗺𝘂𝗻𝗲 𝗰𝗲𝗹𝗹 𝗳𝘂𝗻𝗰𝘁𝗶𝗼𝗻, 𝗹𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲

This video was captured using Nanolive’s label-free imaging platform, which allows the capture of dynamic cell behavior at high resolution, without phototoxicity. Our LIVE T Cell Assay offers label-free, real-time imaging and AI-powered analysis that maintain cell health while delivering continuous insights into T cell activation, engagement, and cytotoxicity.

To learn more, download our flyer: https://x.sfmsg.co/a9w7PAGVP

In this video, we see one CAR T cell single-handedly killing 7 cancer cells in 7 hours! Triggering apoptosis after a brief interaction, the T cell swiftly migrates from target to target. Despite the T cell’s success, one cancer cell still manages to resist, and it is this variation that requires us to research and understand T cells better, to ensure the success of immunotherapies.

You can replay our webinar to hear Dr Roddy O'Connor, Ph.D. from UPenn discuss this video and others here: https://bit.ly/4iYBj4l

What if you could study cells and their organelles without disturbing them?

With Nanolive, cell imaging becomes live and label-free, powered by AI instead of dependent on fluorescent stains and dyes, which can stress cells and shorten experiments. This makes it possible to capture the true complexity of cellular phenotypes in their native state.

With Nanolive, you can profile organelles such as nuclei, nucleoli, mitochondria, and lipid droplets in real time. AI-driven segmentation converts these signals into rich, quantitative data, giving you deeper biological insights while keeping experiments physiologically relevant.

👉 Want to see how organelles and cellular structures really look? Download our organelle guide poster here:
https://x.sfmsg.co/aAG5XzyOA

𝗟𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲, 𝘂𝗻𝗯𝗶𝗮𝘀𝗲𝗱 𝗰𝘆𝘁𝗼𝘁𝗼𝘅𝗶𝗰𝗶𝘁𝘆 𝘀𝗰𝗿𝗲𝗲𝗻𝗶𝗻𝗴

Understanding how cells respond to toxic compounds is a cornerstone of drug discovery, safety testing, and academic research. Yet, most traditional cytotoxicity assays only measure a single endpoint, missing the dynamic morphological changes that provide deep insights into drug function.

By increasing the number of parameters studied with Nanolive’s high-content imaging solutions, researchers can go beyond static measurements. Our label-free, real-time approach reveals how individual cells change over time, uncovering subtle responses such as swelling, vacuolization, or cell death, all without perturbing your samples.

👉 Discover how Nanolive enables more predictive, physiologically relevant cytotoxicity assays with our LIVE Cytotoxicity Assay flyer: https://x.sfmsg.co/aIYyQQvBb

🎥 This video shows endocytic vesicle formation and rapid apoptosis induced by ebastine treatment. These label-free images were captured every 3 mins for 20 h, using a field of view of 275×275 µm.

𝗗𝗼 𝘆𝗼𝘂 𝗵𝗮𝘃𝗲 𝗵𝗮𝗻𝗱𝘀-𝗼𝗻 𝘁𝗲𝗰𝗵𝗻𝗶𝗰𝗮𝗹 𝗮𝗽𝘁𝗶𝘁𝘂𝗱𝗲 𝗮𝗻𝗱 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁 𝗶𝗻 𝗽𝗿𝗼𝗯𝗹𝗲𝗺-𝘀𝗼𝗹𝘃𝗶𝗻𝗴?

We're a Field Application & Service Engineer (US, Remote).
This is an exciting role for a motivated and hands-on individual with a passion for cutting-edge technology and customer engagement. As a 𝗙𝗶𝗲𝗹𝗱 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 (𝟮𝟬%) 𝗮𝗻𝗱 𝗦𝗲𝗿𝘃𝗶𝗰𝗲 (𝟴𝟬%) 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿, this role focuses on post-sales activities, combining the responsibilities of application and service to ensure exceptional customer experience and seamless operation of Nanolive’s systems.

Nanolive is transforming live-cell imaging with cutting-edge technology that seamlessly combines screening, imaging, and AI-powered analysis. Our solutions empower researchers to accelerate discoveries in drug development, cell therapy, and beyond.

💡 If you’re excited by the idea of bridging the gap between technology and customers to make real-world impact, we’d love to meet you!

For more details about the role, please visit: https://bit.ly/3SNAKRI

𝗗𝗶𝘃𝗲 𝗶𝗻𝘁𝗼 𝘁𝗵𝗲 𝘂𝗻𝘀𝗲𝗲𝗻: 𝟯𝗗 𝗹𝗮𝗯𝗲𝗹-𝗳𝗿𝗲𝗲 𝗱𝘆𝗻𝗮𝗺𝗶𝗰𝘀 𝗶𝗻 𝗿𝗲𝗮𝗹-𝘁𝗶𝗺𝗲
Ever wondered how cells interact, respond and grow at a granular level?
Watch as we visualize mitochondrial dynamics and lipid droplets in high-resolution. This time-lapse was captured using Nanolive’s unique technology, with an image frequency of one frame every five seconds (15fps).

By progressively zooming in, we can truly appreciate all the intricate details of these cellular interactions without the need for toxic stains or labels. It is the perfect way to preserve natural cell behavior and capture fast dynamics as they happen.

Explore our solutions for quantifying live cell imaging here: https://bit.ly/4wo4nYr

𝗜𝗺𝗽𝗿𝗼𝘃𝗶𝗻𝗴 𝗼𝗻 𝗲𝗻𝗱𝗽𝗼𝗶𝗻𝘁 𝗱𝗮𝘁𝗮: 𝗹𝗶𝘃𝗲 𝗰𝗲𝗹𝗹 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗳𝗼𝗿 𝗱𝗿𝘂𝗴 𝗱𝗲𝗹𝗶𝘃𝗲𝗿𝘆

In last week’s webinar, Elizabeth Nelson discussed the benefits of a live cell imaging approach vs endpoint methods such as flow cytometry, outlining areas of impact on user workflow as well as data quality.

Investigating nanoparticle delivery with label-free live cell imaging is now available on demand: https://bit.ly/4xNFwyv

Catch up to discover how live cell imaging provides:

– Dynamic, real-time data, beyond static endpoint assays
– Reduced phototoxicity for long-term live cell imaging
– Kinetics of nanoparticle uptake and mRNA release and transcription
– Insights into how nanoparticle formulation impacts delivery dynamics
– Label-free insights into drug mechanism of action and cell response
– More physiologically relevant data for translational research

𝗗𝗼 𝘆𝗼𝘂 𝗵𝗮𝘃𝗲 𝗵𝗮𝗻𝗱𝘀-𝗼𝗻 𝘁𝗲𝗰𝗵𝗻𝗶𝗰𝗮𝗹 𝗮𝗽𝘁𝗶𝘁𝘂𝗱𝗲 𝗮𝗻𝗱 𝗶𝗻𝘁𝗲𝗿𝗲𝘀𝘁 𝗶𝗻 𝗽𝗿𝗼𝗯𝗹𝗲𝗺-𝘀𝗼𝗹𝘃𝗶𝗻𝗴?
We're a Field Application & Service Engineer (US, Remote).

This is an exciting role for a motivated and hands-on individual with a passion for cutting-edge technology and customer engagement. As a 𝗙𝗶𝗲𝗹𝗱 𝗔𝗽𝗽𝗹𝗶𝗰𝗮𝘁𝗶𝗼𝗻 (𝟮𝟬%) 𝗮𝗻𝗱 𝗦𝗲𝗿𝘃𝗶𝗰𝗲 (𝟴𝟬%) 𝗘𝗻𝗴𝗶𝗻𝗲𝗲𝗿, this role focuses on post-sales activities, combining the responsibilities of application and service to ensure exceptional customer experience and seamless operation of Nanolive’s systems.

Nanolive is transforming live-cell imaging with cutting-edge technology that seamlessly combines screening, imaging, and AI-powered analysis. Our solutions empower researchers to accelerate discoveries in drug development, cell therapy, and beyond.

💡 If you’re excited by the idea of bridging the gap between technology and customers to make real-world impact, we’d love to meet you!

For more details about the role, please visit: https://bit.ly/4ejgOyo

𝗟𝗶𝘃𝗲 𝗰𝗲𝗹𝗹 𝗶𝗺𝗮𝗴𝗶𝗻𝗴 𝗰𝗮𝗽𝘁𝘂𝗿𝗲𝘀 𝘄𝗵𝗮𝘁 𝗲𝗻𝗱𝗽𝗼𝗶𝗻𝘁𝘀 𝗰𝗮𝗻’𝘁
Ferroptotic cell death spreads through cell cultures like a wave, as captured here by ‌Ryan Mansell. From the discovery of ferroptosis in 2012, it took 12 more years for this propagation pattern to be discovered and published, which begs the question- what else are we missing when using static endpoints to study studying dynamic processes like cell death?

Next week, researcher Elizabeth Nelson will be sharing their use of live cell imaging to quantify the dynamic processes of nanoparticle uptake, cargo delivery, and drug effects. Register here to learn more about live cell imaging for drug discovery: https://bit.ly/4uqD8Li

To hear Ryan present this label-free ferroptosis video in more detail, catch the replay of our webinar on demand here: https://bit.ly/3PRf6en